首页> 外文期刊>Journal of Periodontology >Optimum force and duration of toothbrushing to enhance gingival fibroblast proliferation and procollagen type I synthesis in dogs.
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Optimum force and duration of toothbrushing to enhance gingival fibroblast proliferation and procollagen type I synthesis in dogs.

机译:最佳刷牙力和持续时间,可增强狗的牙龈成纤维细胞增殖和前胶原I型合成。

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BACKGROUND: Toothbrushing enhances gingival fibroblast proliferation, which promotes wound healing. Optimum force and duration of toothbrushing for stimulation of fibroblast proliferation are key factors in maximizing effects of toothbrushing on periodontal wound healing. We therefore evaluated the effects of different durations and forces of toothbrushing on proliferative activity and procollagen synthesis of gingival fibroblasts. METHODS: Twelve dogs were used. In each dog, buccal gingivae of 12 teeth were examined for 3 weeks. Nine of these 12 teeth were each assigned to 1 of 9 different combinations of brushing force (0.98, 1.96, or 2.45 N) and duration (10, 20, or 40 seconds). The remaining 3 teeth received plaque removal without brushing, via a scaler. RESULTS: Force and duration of toothbrushing affected both proliferating cell nuclear antigen (PCNA)-positive and procollagen Type I C-peptide (PIP)-positive fibroblast ratios (P < 0.05). The highest ratio of PCNA-positive fibroblasts was produced by brushing at 1.96 N for 20 seconds. The highest ratio of PIP-positive fibroblasts was produced by brushing at 1.96 N for 10 seconds. CONCLUSIONS: Toothbrushing at certain forces and durations enhanced the proliferative activity and procollagen synthesis of gingival fibroblasts. The toothbrushing duration that increased procollagen synthesis (10 seconds) was shorter than that which increased fibroblast proliferative activity (20 seconds).
机译:背景:刷牙可促进牙龈成纤维细胞增殖,从而促进伤口愈合。最佳的牙刷刷牙力和持续时间是刺激成纤维细胞增殖的关键因素,是使牙刷对牙周伤口愈合的作用最大化的关键因素。因此,我们评估了不同持续时间和牙刷力度对牙龈成纤维细胞增殖活性和胶原蛋白合成的影响。方法:使用十二只狗。在每只狗中,检查12颗牙齿的颊齿龈3周。这12颗牙齿中的9颗分别分配了9种不同的刷牙力(0.98、1.96或2.45 N)和持续时间(10、20或40秒)的组合。剩下的3颗牙齿通过洁牙机无需刷牙即可去除牙菌斑。结果:牙刷的作用力和持续时间会影响增殖细胞核抗原(PCNA)阳性和前胶原I型C肽(PIP)阳性成纤维细胞比率(P <0.05)。 PCNA阳性成纤维细胞的最高比例是通过在1.96 N下刷20秒来产生的。 PIP阳性成纤维细胞的最高比例是通过在1.96 N的压力下刷牙10秒钟来产生的。结论:在一定的作用力和持续时间下,牙刷可以增强牙龈成纤维细胞的增殖活性和胶原蛋白的合成。增加前胶原合成的牙刷持续时间(10秒)比增加成纤维细胞增殖活性的牙刷持续时间(20秒)短。

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