血清Ⅰ型前胶原氨基端前肽、Ⅰ型前胶原羧基端前肽、Ⅰ型胶原羧基端肽在骨转移性癌诊断中的应用

摘要

Objective:To study the clinical value of determination of serum procollagen I N-terminal propeptide (PINP), pro-collagen I carboxy-terminal propeptide (PICP) and carboxyterminal telopeptide of type I collagen (ICTP) contents in cancer patients with bone metastases for diagnosis . Methods- Serum PINP, PICP and ICTP contents were measured in 41 patients with bone metastases and 39 controls without bone metastases. The patients with bone metastases consisted of Group A, Group B and Group C. The comparison of bone turnovers among patients with different bone loads were analyzed. Results.- Serum PICP, ICTP contents was significantly greater in patients with bone metastases than without bone metastases(P<0. 01). With the increase of the extent of bone metastases, serum PINP, PICP and ICTP contents elevated. Levels of PICP correlated well to the number of foci(P<0. 01) , Levels of ICTP, PINP correlated to the number of foci(P<0. 05). Levels of PINP correlated well to ICTP. Conclusions: The determinations of serum PINP, PICP and ICTP can reflect the clinical status of metastases size (PICP and ICTP more sensitive); Levels of PICP correlat well to the number of foci.%目的;探讨血清Ⅰ型前胶原氨基端前肽( PINP)、Ⅰ型前胶原羧基端前肤(PICP)、Ⅰ型胶原羧基端肽(ICTP)在骨转移癌诊断中的临床价值.方法:将80例肿瘤患者分为骨转移组41例和无骨转移组(对照组)39例,采用Soloway分级标准,将骨转移组患者再分为A、B、C3个亚组,所有患者空腹抽取静脉血.分析血清PINP、PICP、ICTP与骨转移程度之间的相关性及其彼此之间的相关性.结果:骨转移癌患者血清PINP、PICP、ICTP水平较对照组均升高,其中PICP、ICTP水平与对照组有显著差异(P＜0.01)；PINP、PICP、ICTP水平在A、B、C3组均依次递增；血清PICP水平与骨转移灶数目相关性良好(P＜0.01),ICTP、PINP水平与骨转移灶数目呈一定相关(P＜0.05)；血清ICTP水平与PINP水平呈中度相关.结论:检测血清PINP、PICP、ICTP水平都能反映骨转移患者的病情变化,以检测血清PICP、ICTP水平临床价值高；血清PICP水平与骨转移数目的相关性良好.