Preparation of C-18-functionalized Fe3O4@SiO2 core-shell magnetic nanoparticles for extraction and determination of phthalic acid esters in Chinese herb preparations

摘要

The extraction and determination of phthalic acid esters (PAEs) residue in Chinese herbal preparations (CHP) by C-18-functionalized magnetic nanoparticles (C-18-FS-MNP) has been firstly performed. It was synthesized through coating Fe3O4 nanoparticles with sodium silicate, followed by freeze-drying technique and then modified with C-18 groups. C-18-FS-MNPs prepared via freeze-drying technique were superior to those particles prepared via common vacuum drying method in terms of dispersion and extraction recovery. C-18-FS-MNPs demonstrated obvious enrichment effect for four model PAEs and 478-627-fold enrichment factors were obtained. The limit of detection was <1.89 ng/mL and relative standard deviation was ranging from 3.7 to 5.8%. It was successfully applied for determination of trace PAEs residue in CHP with good recoveries. (C) 2014 Elsevier B.V. All rights reserved.