Irsogladine maleate regulates barrier function and neutrophil accumulation in the gingival epithelium

摘要

Epithelial cells function as mechanical barriers against invasion by pathogenic organisms and promote intercellular communication through cell-cell junction complexes. Therefore, the permeability of the gingival epithelial cell layer indicates a defensive capability against invasion by periodontal pathogens. Accumulation of activated neutrophils is thought to be involved in the onset of inflammation. Here, we review the effects of irsogladine maleate, a medication for gastric ulcers, on E-cadherin and chemokine expression in gingival epithelial cells exposed to periodontopathogenic bacteria, in order to examine the clinical efficacy of irsogladine maleate in preventing periodontal inflammation.