Renal safety with pamidronate (PAM) 1-hour infusion for metastastic breast cancer (MBC) and multiple myeloma (MM): a multi-mentred, population-based analysis

摘要

Purpose: American Society of Clinical Oncology (ASCO) guidelines recommend PAM be infused over 2 hours to avoid renal deterioration (RD). BCCA recommends 1-hr PAM infusions based on reported safely from two case series, one randomized controlled trial (RCT) (ASCO 1999 abstract 2223) and one retrospective analysis (ASCO 2002 abstract 208) The study goal is to confirm the safety of 1-hr PAM infusions and thereby facilitate optimal use of healthcare resources.