Schisandrene,a Dibenzocyclooctadiene Lignan from Schisandra chinensis: Structure-Antioxidant Activity Relationships of Dibenzocyclooctadiene Lignans

摘要

Phytochemical investigation of the fruits of Schisandra chinensis led to the isolation of 13 lignans including schisandrene (13),a new lignan based on a dibenzocyclooctadiene backbone with an exocyclic double bond.Its structure and absolute configuration were established using NMR,MS,and CD data.Antioxidant activity of the lignans was evaluated using a DCFH-DA cellular-based assay.The structure- activity relationships of the dibenzocyclooctadiene lignans showed that the exocyclic methylene functionality was essential for antioxidant activity,with the benzoyloxy group probably enhancing such effects.