Isolation, structure determination, and anti-HIV evaluation of Tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.

摘要

Five novel tigliane-type diterpenes, stelleracins A-E (3-7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from the roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds 3-5 showed potent anti-HIV activity (EC₉₀ 0.00056-0.0068 micro M) and relatively low or no cytotoxicity (IC₅₀ 4.4-17.2 micro M). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates.