Micellar interaction study of synthetic antioxidant (BHA) and sodium dodecyl sulfate (SDS) in aqueous solution for potential pharmaceutical/food applications

摘要

Butylated hydroxyanisole (BHA) is a potential phenolic antioxidant which has a wide range of pharmacological actions, whereas, sodium dodecyl sulfate (SDS) is well known to form colloidal aggregates which can be employed for biological processes, and as effective vehicles for delivery and transport phenomena. Therefore, it would be interesting to evaluate the interactions between BHA-SDS and impact of BHA-SDS micellar properties. Aggregation in terms of CMCs and thermo-acoustic properties via specific conductivity (κ), viscosity (η), compressibility coefficient (β), apparent molar volume (phgr_v) and apparent molar adiabatic compressibility (phgr _k) of SDS in aqueous solutions containing BHA at different temperatures (25, 30, 35 and 40 C) have been measured. Proton NMR analysis was performed in the absence and presence of BHA. Interactions were evaluated in terms of chemical shifts and moreover provided perceptivity on the location of BHA within the micelle. The results revealed the significant contribution of BHA to promoting the micelle formation much earlier with regard to increase in concentration and temperature. Convincingly, this study not only casts light on the binding interactions but also provides a hint to utilizing the micellar system in stabilization and maintenance of pharmaceutical and food materials.