Sarcolemmal Ca2+-entry through L-type Ca2+ channels controls the profile of Ca2+-activated Cl- current in canine ventricular myocytes

Horvath Balks; Vaczi Krisztina; Hegyi Bence; Gonczi Monika; Dienes Beatrix; Kistamas Kornel; Banyasz Tamas; Magyar Janos; Baczko Istvan; Varro Andras; Seprenyi Gyorgy; Csernoch Laszlo; Nanasi Peter P.; Szentandrassy Norbert

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Sarcolemmal Ca2+-entry through L-type Ca2+ channels controls the profile of Ca2+-activated Cl- current in canine ventricular myocytes

机译：通过L型Ca2 +通道进入肌膜的Ca2 +可控制犬心室肌细胞中Ca2 +激活的Cl-电流的分布

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Ca2+-activated Cl- current (I-Cl(Ca)) mediated by TMEM16A and/or Bestrophin-3 may contribute to cardiac arrhythmias. The true profile of I-Cl(Ca) during an actual ventricular action potential (AP), however, is poorly understood.

机译：TMEM16A和/或Bestrophin-3介导的Ca2 +激活的Cl-电流（I-Cl（Ca））可能会导致心律不齐。然而，人们对I-Cl（Ca）在实际心室动作电位（AP）期间的真实轮廓知之甚少。

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《Journal of Molecular and Cellular Cardiology 》 |2016年第null期| 共15页
作者
Horvath Balks; Vaczi Krisztina; Hegyi Bence; Gonczi Monika; Dienes Beatrix; Kistamas Kornel; Banyasz Tamas; Magyar Janos; Baczko Istvan; Varro Andras; Seprenyi Gyorgy; Csernoch Laszlo; Nanasi Peter P.; Szentandrassy Norbert;
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正文语种 eng
中图分类心脏、血管（循环系）疾病 ;
关键词
Ca2+-activated Cl- current; Canine cardiomyocytes; Action potential voltage-clamp; TMEM16A; Bestrophin-3; Human cardiomyocytes;

机译：Ca2 +激活的Cl-电流;犬心肌细胞;动作电位钳位;TMEM16A;Bestrophin-3;人类心肌细胞;

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1. Sarcolemmal Ca2+-entry through L-type Ca2+ channels controls the profile of Ca2+-activated Cl- current in canine ventricular myocytes [J] . Horvath Balks, Vaczi Krisztina, Hegyi Bence, Journal of Molecular and Cellular Cardiology . 2016 ,第Null期

机译：通过L型Ca2 +通道进入肌膜的Ca2 +可控制犬心室肌细胞中Ca2 +激活的Cl-电流的分布
2. The inhibitory effect of Ca2+-activated K+ channel activator, BMS on L-type Ca2+ channels in rat ventricular myocytes. [J] . Son YK, Choi SW, Jung WK, Life sciences . 2011 ,第9a10期

机译：Ca2 +活化K +通道活化剂，BMS对大鼠心室肌细胞L型Ca2 +通道的抑制作用。
3. The inhibitory effect of Ca2+-activated K+ channel activator, BMS on L-type Ca2+ channels in rat ventricular myocytes. [J] . Son YK, Choi SW, Jung WK, Life sciences . 2011 ,第9a10期

机译：Ca2 +活化K +通道活化剂，BMS对大鼠心室肌细胞L型Ca2 +通道的抑制作用。
4. Effects of L-type Ca2+ channel blocker nifedipine on dynamic arterial blood pressure control [C] . Kawada Toru, Yamamoto Hiromi, Shimizu Shuji, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2013

机译：L型Ca 2 + / sup>通道阻滞剂硝丁平对动态动脉血压控制的影响
5. Modulation of the pharmacology of Ca2+-activated Cl- channels of pulmonary artery smooth muscle cells and the molecular candidate TMEM16A by phosphorylation. [D] . Wiwchar, Michael. 2010

机译：通过磷酸化调节肺动脉平滑肌细胞Ca2 +激活的Cl-通道和分子候选TMEM16A的药理作用。
6. Ca2+ influx via the L-type Ca2+ channel during tail current and above current reversal potential in ferret ventricular myocytes [O] . Zhuan Zhou, Donald M Bers 2000

机译：尾电流及高于电流反向电位的雪貂心室肌细胞中Ca2 +通过L型Ca2 +通道流入
7. Sarcolemmal Ca2+-entry through L-type Ca2+ channels controls the profile of Ca2+-activated Cl- current in canine ventricular myocytes [O] . Horváth, Balázs, Váczi, Krisztina, Hegyi, Bence, 2017

机译：通过L型Ca2 +通道的sarcolemmal Ca2 + -entry控制犬心室肌细胞中Ca2 +激活的Cl-电流的分布
8. Block of Single L-Type Ca2+ Channels in Skeletal Muscle Fibers by AminoglycosideAntibiotics [R] . Haws, C. M., Winegar, B. D., Lansman, J. B. 1996

机译：氨基糖苷类抗生素对骨骼肌纤维中单个L型Ca2 +通道的阻断

Sarcolemmal Ca2+-entry through L-type Ca2+ channels controls the profile of Ca2+-activated Cl- current in canine ventricular myocytes

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