Synthesis and in Vitro Antileukemic Activity of Some New l,3-(Oxytetraethylenoxy)cyclotriphosphazene Derivatives

摘要

A new series of l,3-(oxytetraethylenoxy)cyclotriphosphazene derivatives bearing 2-chloroethylamine or salicylaldehyde (2-hydroxybenzaldehyde) or its Schiff base (after condensation with 2-chloroethylamine) units and having also 2-naphthyl or anthraquinone groups as cosubstituents has been synthesized.The in vitro cytotoxic activity of these compounds against a panel of four cancer cell lines has been studied.Most of the compounds exhibited antiproliferative activity in the range of the international criterion for synthetic agents (4 mu g/mL) against the MOLT4,L 1210,HL-60,and P388 cell lines chosen for testing.