Discovery, Biological Evaluation, and Structure-Activity Relationship of AmDEine Based Sphingosine Kinase Inhibitors

摘要

Sphingosine 1-phosphate (S1P), a potent phospholipDE growth and trophic factor, is synthesized in vivo by two sphingosine kinases. Thus these kinases have been proposed as important drug targets for treatment of hyperproliferative diseases and inflammation. We report here a new class of amDEine-based sphingosine analogues that are competitive inhibitors of sphingosine kinases exhibiting varying degrees of enzyme selectivity. These inhibitors display K-I values in the submicromolar range for both sphingosine kinases and, in cultured vascular smooth muscle cells, decrease S1P levels and initiate growth arrest.