Medicinal Chemistry of hERG Optimizations:Highlights and Hang-Ups

摘要

In recent years,withdrawal of marketed drugs including sertindole,grepafloxacin,and terfenadine owing to prolongation of the length of time between the start of the Q wave and end of the T wave on an electrocardiogram (QT interval) has prompted considerable effort in trying to establish the molecular basis of this potentially lethal phenomenon.