Development of a Three-Dimensional Model for the N-Methyl-D-aspartate NR2A Subunit

摘要

NR2 subunits of N-methyl-D-aspartic acid (NMDA) receptors are known to bind the neurotrans-mitter glutamate,competitive agonists,and antagonists.Since crystallographic data of these proteins are not available,we built a homology model of the ligand binding domain of the NR2A subunit.A consensus binding mode of selected AP5-like NMDA antagonists has been ascertained using molecular docking.The present 3D model gives insights for the design of new NMDA subtype selective compounds.