Phytochemical analysis and in vitro antimicrobial activity of stem bark extracts of Aibizia lebbeck (L.) Benth

摘要

Antimicrobial activity of stem bark of Albizia lebbeck was studied against seven pathogenic bacteria and three fungal strains by agar well diffusion method. Antimicrobial activity was recorded for hexane, chloroform, methanol, ethanol and aqueous extracts. Alcohol (ethanol and methanol) extracts exhibited higher degree of antimicrobial activity compared to chloroform, hexane and aqueous extracts. Escherichia coli was turned out be the most susceptible bacterium to the crude stem bark chemical constituents using the standard tetracycline and nystatin. Minimum inhibition concentration values of hexane, chloroform, methanol, ethanol and aqueous extracts determined by the agar dilution method ranged between 31.2 and 1000 pg. The study suggested that the stem bark extracts possess bioactive compounds with antimicrobial activity against the tested bacteria and fungi revealing a significant scope to develop a novel broad spectrum of antimicrobial drug formulation from A. lebbeck.