INVITRO ANTICANCER ACTIVITY OF LEAF EXTRACT OF ALBIZIA LEBBECK (BENTH): PRODUCING THE SAME

摘要

Medicinal plants are traditionally used in folk medicine as natural healing remedies with therapeutic effects such as prevention of cardiovascular diseases or reducing the risk of cancer. The present study was designated to evaluate the antibacterial and phytochemical activity from the leaves and bark ofAlbizzia lebbeck. The result of hydroalcohol extracts of leaf showed better antimicrobial activity followed by the bark extracts. The extracts of Albizzia lebbeck showed better inhibition towards Escherichia coli and Salmonella typhi when compared with Cefoperazone/ Tazobactam. The objective of the present work is to study the invitro antioxidant activity by DPPH scavenging, Nitric oxide assay, hydrogen peroxide, sulphur oxide and total antioxidant assays. The results revealed that the hydroalcoholic leaves extracts of Albizia lebbeck showed a strong antioxidant activity, reducing power ability and free radical scavenging when compared to the standard such as Ascorbic acid. The results on the cytotoxicity tests conducted against human breast adenocarcinoma (MCF-7) and human prostate cancer cell line (PC- 3) showing a certain degree of selectivity against the different cell types.