A continuous challenge from Gram-negative bacteria: more carbapenemases.

摘要

A new type of carbapenemase, New Delhi metallo-(3-lactamase (NDM)-l, has been recently identified in Enterobacteriacae isolates. Multidrug resistant NDM-1 pathogens spread quickly and caused human infections in the community and hospitals in many countries. This finding has attracted worldwide attentions.1 The bladm-1 gene encodes an enzyme, which confers resistance to car-bapenems and other p-lactams. The bladm-1 gene harbors in Enterobacteriacae, mainly Klebsiella pneumoniae and Escherichia coli, which can cause community-onset or healthcare-associated infections. The first case of NDM-1 infection was found in a Swedish patient of India origin, who has been admitted to a hospital in New Delhi.