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首页> 外文期刊>Journal of Korean medical science >Serum procalcitonin for differentiating bacterial infection from disease flares in patients with autoimmune diseases.
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Serum procalcitonin for differentiating bacterial infection from disease flares in patients with autoimmune diseases.

机译:血清降钙素原可用于区分自身免疫性疾病患者的细菌感染和疾病发作。

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Early differentiation between bacterial infections and disease flares in autoimmune disease patients is important due to different treatments. Seventy-nine autoimmune disease patients with symptoms suggestive of infections or disease flares were collected by retrospective chart review. The patients were later classified into two groups, disease flare and infection. C-reactive protein (CRP) and serum procalcitonin (PCT) levels were measured. The CRP and PCT levels were higher in the infection group than the disease flare group (CRP,11.96 mg/dL +/- 9.60 vs 6.42 mg/dL +/- 7.01, P = 0.003; PCT, 2.44 ng/mL +/- 6.55 vs 0.09 ng/mL +/- 0.09, P < 0.001). The area under the ROC curve (AUC; 95% confidence interval) for CRP and PCT was 0.70 (0.58-0.82) and 0.84 (0.75-0.93), which showed a significant difference (P < 0.05). The predicted AUC for the CRP and PCT levels combined was 0.83, which was not significantly different compared to the PCT level alone (P = 0.80). The best cut-off value for CRP was 7.18 mg/dL, with a sensitivity of 71.9% and a specificity of 68.1%. The best cut-off value for PCT was 0.09 ng/mL, with a sensitivity of 81.3% and a specificity of 78.7%. The PCT level had better sensitivity and specificity compared to the CRP level in distinguishing between bacterial infections and disease flares in autoimmune disease patients. The CRP level has no additive value when combined with the PCT level when differentiating bacterial infections from disease flares.
机译:由于治疗方法的不同,早期区分自身免疫性疾病患者的细菌感染和疾病发作很重要。通过回顾性图表审查,收集了79例提示感染或疾病发作的自身免疫病患者。随后将患者分为疾病爆发和感染两类。测量C反应蛋白(CRP)和血清降钙素(PCT)的水平。感染组的CRP和PCT水平高于疾病爆发组(CRP为11.96 mg / dL +/- 9.60 vs 6.42 mg / dL +/- 7.01,P = 0.003; PCT为2.44 ng / mL +/- 6.55 vs 0.09 ng / mL +/- 0.09,P <0.001)。 CRP和PCT的ROC曲线下面积(AUC; 95%置信区间)为0.70(0.58-0.82)和0.84(0.75-0.93),显示出显着差异(P <0.05)。 CRP和PCT含量的合并预测的AUC为0.83,与单独的PCT含量相比无显着差异(P = 0.80)。 CRP的最佳临界值为7.18 mg / dL,灵敏度为71.9%,特异性为68.1%。 PCT的最佳临界值为0.09 ng / mL,灵敏度为81.3%,特异性为78.7%。与CRP水平相比,PCT水平在区分自身免疫性疾病患者的细菌感染和疾病发作方面具有更好的敏感性和特异性。当区分细菌感染和疾病爆发时,CRP水平与PCT水平结合时没有累加值。

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