A NEW STRATEGY FOR LABELING BIOMQLECULES THAT CONTAIN DISULFIDE BONDS WITH RHENIUM AND TECHNETIUM

摘要

Labeling biomolecules that contain disulfide bonds with radiometals like ~99mTc and ~188Re is problematic. Typical labeling procedures often result in the reduction of disulfide bonds, which disrupts the structure and hence bioactivity of the parent compound. Even indirect labeling procedures, which are of use for basic research studies, can disrupt disulfide bonds through redox type reactions.