Oxidation Products of N-nitrosodialkylamines Generated by Fenton's Reagent in the Presence of Copper Are Direct Acting Mutagens

摘要

N-Nitrosodialkylamines, activated metabolically by cytochrome P450, possess mutagenic and carcinogenic activity. In this study, the hydroxyl radical, generated from Fenton's reagent, was used as an oxidant for the activation of the N-nitrosodialkylamines. Ethyl acetate extract from the reaction mixture which included Fe~(2+)-Cu~(2+)-H_2O_2 and N-nitrosodialkylainines; N-nitrosodimethylamine (NDM), A