Possible hepatosplenic candidiasis treated with liposomal amphotericin B and caspofungin combination.

摘要

Combination anti-fungal therapy is one of the hottest topics in the infectious diseases. Recently, Nivoix et al. reported 20 cases of fungal infection treated with combination of caspofungin and an azole or an amphotericin B formulation in invasive fungal infections.Despite several developments in the quality of care and anti-microbial therapy, febrile neutropeniais still a morbid and mortal syndrome. In spite of extended spectrum anti-bacterial and anti-fungal agents, fever may persist in several situations.Hepatosplenic candidiasis (HSC) is a potentially mortal complication encountered in immunocompromisedor febrile neutropenic individuals, especially, those being treated with intensive chemotherapy protocols for acute leukaemia. Immediate recognition of this complication and initiation of appropriate treatment is crucial in order to control the infection, decrease the morbidity and mortality, and avoid delays in treatment of the underlying condition.