Synthesis and Antibacterial Activity of New 2,5-Diaryl-3-styryl- 4H,2,3,3a,5,6,6a-hexahydropyrrolo[3,4-d]isoxazole-4,6-diones

摘要

The synthesis of some biologically interesting pyrrolo-isoxazolidine derivatives has been accomplished by the 1,3-dipolar cycloaddition reaction of substituted open chain conjugated azomethine N-oxides 1 with substituted N-aryl maleimides 2 leading to the formation of new stereoisomeric 2,5-diaryl-3-styryl- 4H,2,3,3a,5,6,6a-hexahydropyrrolo[3,4-d]isoxazole-4,6-dione derivatives 3 in excellent yields. These stereoisomers have been characterized as cis-3A and trans-3B on the basis of their ~1H-NMR spectral measurements. The synthesized compounds have been screened for their antibacterial activities and have been found to be active against the bacteria Escherichia coli and Pseudomonas aeruginosa up to a significant extent.