SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma

Zhang Zheng Yun; Hong Doopyo; Nam Seung Hoon; Kim Jong Man; Paik Yong Han; Joh Jae Won; Kwon Choon Hyuck David; Park Jae Berm; Choi Gyu-Seong; Jang Kyu Yun; Park Cheol Keun; Kim Sung Joo

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SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma

机译：SIRT1通过突变的p53依赖性途径调节肝细胞癌的发生。

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Background & Aims: SIRT1 is a class III histone deacetylase that plays diverse roles in various cancers. However, the clinical significance of SIRT1 in hepatocellular carcinoma (HCC) remains unknown.

机译：背景与目的：SIRT1是一种III类组蛋白脱乙酰基酶，在多种癌症中起着不同的作用。但是，SIRT1在肝细胞癌（HCC）中的临床意义仍然未知。

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《Journal of Hepatology: The Journal of the European Association for the Study of the Liver》 |2015年第1期|共10页
作者
Zhang Zheng Yun; Hong Doopyo; Nam Seung Hoon; Kim Jong Man; Paik Yong Han; Joh Jae Won; Kwon Choon Hyuck David; Park Jae Berm; Choi Gyu-Seong; Jang Kyu Yun; Park Cheol Keun; Kim Sung Joo;
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正文语种 eng
中图分类消化系及腹部疾病;
关键词
SIRT1; AMPK; mTOR; Metformin; p53;

机译：SIRT1;AMPK;mTOR;二甲双胍;p53;

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专利

1. 整合型HBVDNA前C区突变和p53基因突变与肝细胞癌发生的关系 [J] . 王修海, 王培林癌症（英文版） . 2003,第007期
2. SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma [J] . Zhang Zheng Yun, Hong Doopyo, Nam Seung Hoon, Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2015,第1期

机译：SIRT1通过突变的p53依赖性途径调节肝细胞癌的发生。
3. Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin [J] . Wen Jing Lu, Nikki P. Lee, Sunil C. Kaul, International Journal of Cancer =: Journal International du Cancer . 2011,第8期

机译：靶向应激蛋白mortalin诱导人肝癌突变型p53依赖性细胞凋亡
4. Notch1 differentially regulates oncogenesis by wildtype p53 overexpression and p53 mutation in grade III hepatocellular carcinoma. [J] . Lim SO, Park YM, Kim HS, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2011,第4期

机译：Notch1通过野生型p53过表达和p53突变在III级肝细胞癌中差异调节肿瘤发生。
5. Multi-omic Pathway and Network Analysis to Identify Biomarkers for Hepatocellular Carcinoma [C] . Megan E. Barefoot, Rency S. Varghese, Yuan Zhou, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

机译：多组学途径和网络分析，以鉴定肝细胞癌的生物标志物
6. Sirt1 Deficiency Upregulates Glutathione Metabolism to Prevent Hepatocellular Carcinoma Initiation in Mice [D] . Qiu, Pengxiang. 2021

机译：SIRT1缺乏上调谷胱甘肽代谢以预防小鼠肝细胞癌的起始
7. Engagement with tNOX (ENOX2) to Inhibit SIRT1 and Activate p53-Dependent and -Independent Apoptotic Pathways by Novel 411-Diaminoanthra23-bfuran-510-diones in Hepatocellular Carcinoma Cells [O] . Chia-Yang Lin, Atikul Islam, Claire J. Su, 2019

机译：参与tNOX（ENOX2）抑制SIRT1并激活新型411-二氨基蒽23-b呋喃-510-二酮在肝癌细胞中的p53依赖性和非依赖性凋亡途径。
8. Engagement with tNOX (ENOX2) to Inhibit SIRT1 and Activate p53-Dependent and -Independent Apoptotic Pathways by Novel 4,11-Diaminoanthra2,3-bfuran-5,10-diones in Hepatocellular Carcinoma Cells [O] . Chia-Yang Lin, Atikul Islam, Claire J. Su, 2019

机译：与TNOX（ENOX2）接触以抑制SIRT1并激活P53依赖性和依赖性凋亡途径，通过新的4,11-二氨基属2,3-B呋喃-5,10-10-10-10-10-10-10-10-10-10-10-10-10-10-10-10-10-10-10-10-10-10-硫酮

SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma

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