Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A

Akamatsu Sakura; Hayes C. Nelson; Ochi Hidenori; Uchida Takuro; Kan Hiromi; Murakami Eisuke; Abe Hiromi; Tsuge Masataka; Miki Daiki; Akiyama Rie; Hiraga Nobuhiko; Imamura Michio; Aikata Hiroshi; Kawaoka Tomokazu; Kawakami Yoshiiku; Chayama Kazuaki

首页> 外文期刊>Journal of Hepatology: The Journal of the European Association for the Study of the Liver >Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A

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Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A

机译：干扰素λ4基因座变异与丙型肝炎病毒非结构蛋白5A替代之间的关联

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Background & Aims: Single nucleotide polymorphisms within the interferon lambda 4 (IFNL4) locus are strongly associated with spontaneous clearance of hepatitis C virus (HCV) infection and early viral response to interferon therapy. Interaction between host genotype and amino acid substitutions might also influence the risk of antiviral resistance in interferon-free direct acting antiviral (DAA) therapies.

机译：背景与目的：干扰素λ4（IFNL4）位点内的单核苷酸多态性与丙型肝炎病毒（HCV）感染的自发清除以及对干扰素治疗的早期病毒反应密切相关。宿主基因型和氨基酸取代之间的相互作用也可能影响无干扰素直接作用抗病毒（DAA）治疗中抗病毒耐药性的风险。

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《Journal of Hepatology: The Journal of the European Association for the Study of the Liver》 |2015年第3期|共10页
作者
Akamatsu Sakura; Hayes C. Nelson; Ochi Hidenori; Uchida Takuro; Kan Hiromi; Murakami Eisuke; Abe Hiromi; Tsuge Masataka; Miki Daiki; Akiyama Rie; Hiraga Nobuhiko; Imamura Michio; Aikata Hiroshi; Kawaoka Tomokazu; Kawakami Yoshiiku; Chayama Kazuaki;
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正文语种 eng
中图分类消化系及腹部疾病;
关键词
Interferon lambda 4; NS5A; ISDR; HCV core protein; Quasispecies; Direct acting antivirals; Daclatasvir; Antiviral resistance; Positive selection; Next generation sequencing;

机译：Lambda 4干扰素;NS5A;ISDR;HCV核心蛋白;准种;直接作用抗病毒剂;达卡他韦;抗病毒抗性;正选择;下一代测序;

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1. Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A [J] . Akamatsu Sakura, Hayes C. Nelson, Ochi Hidenori, Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2015,第3期

机译：干扰素λ4基因座变异与丙型肝炎病毒非结构蛋白5A替代之间的关联
2. Modulation of interferon signaling by hepatitis C virus non-structural 5A protein: implication of genotypic difference in interferon treatment. [J] . Kang SM, Won SJ, Lee GH, FEBS letters. . 2010,第18期

机译：丙型肝炎病毒非结构性5A蛋白对干扰素信号传导的调节：干扰素治疗中基因型差异的含义。
3. The global origins of resistance-associated variants in the non-structural proteins 5A and 5B of the hepatitis C virus [J] . Anita Y M Howe, Bradley R Jones, Jeffrey B Joy, Virus Evolution . 2018,第1期

机译：丙型肝炎病毒非结构蛋白5A和5B中与耐药性相关的变异的全球起源
4. In Vitro Selection of Peptides Against Non-structural 5A Protein of Hepatitis C Virus [C] . Tatsuya Watanabe, Tetsuro Suzuki, Hiroaki Suga Pacific rim conference on ceramic and glass technology . 2010

机译：对丙型肝炎病毒非结构5A蛋白的肽的体外选择
5. Modulation of the host cell signaling pathways and protein synthesis by hepatitis C virus nonstructural 5A protein. [D] . He, Yupeng. 2002

机译：丙型肝炎病毒非结构性5A蛋白调节宿主细胞信号通路和蛋白合成。
6. The global origins of resistance-associated variants in the non-structural proteins 5A and 5B of the hepatitis C virus [O] . Bradley R Jones, Anita Y M Howe, P Richard Harrigan, 2018

机译：丙型肝炎病毒非结构蛋白5A和5B中与耐药相关变异的全球起源
7. Modulation of interferon signaling by hepatitis C virus non-structural 5A protein: Implication of genotypic difference in interferon treatment [O] . Kang Sang-Min, Won Seung-Jae, Lee Gun-Hee, 2010

机译：丙型肝炎病毒非结构性5A蛋白对干扰素信号传导的调节：干扰素治疗中基因型差异的含义

Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A

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