丙型肝炎病毒非结构蛋白5A的研究进展

摘要

丙型肝炎是由丙型肝炎病毒(HCV)引起的非甲-非乙型肝炎,是慢性肝病的主要原因之一.HCV编码至少10种成熟蛋白,而非结构蛋白5A(NS5A)是其重要蛋白之一.磷酸化的NS5A与病毒的复制密切相关,参与病毒的产生和释放,并且能够通过病毒和宿主细胞的相互作用,干扰细胞内重要信号通路,影响细胞周期和免疫系统,最终促使HCV相关慢性肝病的发生与发展.本文就NS5A的生物学功能及其作用机制的研究进展作一综述.%Hepatitis C virus ( HCV) is one of the major causes of chronic non - A, non - B hepatitis. The HCV codes at least ten mature proteins and the non - structural protein 5A (NS5A) is one of the important proteins encoded by HCV. It is an essential component of the HCV replicase and involved in the production and release of the virus. NS5A phosphorylation exerts a wide range of effects on cellular pathways and processes, including innate immunity and host cell growth, involved in HCV -related chronic liver disease. In this paper, we reviewed the biological function and its pathogenic role of HCV NS5A protein.