2-pirrolidin-3-il-1h-imidazol derivative as a nonstructural protein inhibitor of hepatitis C virus 5A

摘要

IT REFERS TO A COMPOUND OF FORMULA (I) WHERE: A 'IS A SIMPLE LINK, IMIDAZOL, TIAZOL, BENCIMIDAZOLE, AMONG OTHERS; B AND B 'ARE TOGETHER PIRROLO [1,2-b] PIRIDAZINA, INDOLIZINA, PIRROLO [1,2-c] PIRIMIDINA; IMIDAZO [1,2-a] PYRIMIDINE, AMONG OTHERS; W IS OF PREFERENCE PIRROL; Y, Y 'ARE EACH ONE C, N; Z AND Z 'ARE EACH ONE H, C1-C8 ALKYL, C1-C8 HETEROALKYL, CYCLOALKYL, ARYL, AMONG OTHERS; Ra ES OH, CN, NO2, HALOGEN, C1-C12 ALKYL, AMONG OTHERS; Rc, Rd, Re and Rf ARE EACH ONE H, C1-C8 ALKYL, C1-C8 HETEROALKYL, ARALKYL, CYCLOALKYL, AMONG OTHERS;R is an independent 0-3 integer. A pharmaceutical composer was also mentioned This compound can inhibit the nonstructural protein 5utl in the treatment of hepatitis C.