Derivatives 2 - pyrrolidin-3-yl - 1H imidazole, as nonstructural 5a Protein inhibitors of hepatitis C virus

摘要

Refers to a compound of formula (i) where a is a single link, imidazole, thiazole, benzimidazole, among others; b and B 'are together pirrolo [1,2-b] pyridazine hydrochloride, indolizina, pirrolo [1,2-c] pyrimidine; imidazo [1,2-a] pyrimidine, among others; W pyrrole is Preferred; and', and are each C, N; Z and Z ' Each one is H, alkyl C8 heteroalquilo C1 C1, C8, cycloalkyl, aryl, among others; ra's Oh, CN,NO2, halogen, alkyl of C1 - C12, among others, RC, RD, re and RF are each h, alkyl C8 heteroalquilo C1 C1, C8, aralquilo, cycloalkyl, among others; R is independently an integer of 0 - 3. Also referred to a Pharmaceutical composition. Said Compound is nonstructural 5a Protein inhibitor used in the treatment of hepatitis C