Morin hydrate attenuates Staphylococcus aureus virulence by inhibiting the self-assembly of alpha-hemolysin

Wang J.; Zhou X.; Liu S.; Li G.; Shi L.; Dong J.; Li W.; Deng X.; Niu X.

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Morin hydrate attenuates Staphylococcus aureus virulence by inhibiting the self-assembly of alpha-hemolysin

机译：桑色素水合物通过抑制α-溶血素的自组装而减弱金黄色葡萄球菌的毒力

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AimsTo investigate the mechanism by which morin hydrate inhibits the haemolytic activity of -hemolysin (Hla), a channel-forming toxin that is important for the pathogenesis of disease in experimental animals, and its therapeutic effect against Staphylococcus aureus pneumonia in a mouse model.

机译：目的探讨水合蛋白水合物抑制-溶血素（Hla）的溶血活性的机制，该溶血素对实验动物疾病的发生具有重要意义，它是一种通道形成毒素，并且对小鼠模型中的金黄色葡萄球菌肺炎具有治疗作用。

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来源
《Journal of applied microbiology》 |2015年第3期|共11页
作者
Wang J.; Zhou X.; Liu S.; Li G.; Shi L.; Dong J.; Li W.; Deng X.; Niu X.;
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正文语种 eng
中图分类应用微生物学;
关键词
anti-virulence; morin hydrate; Staphylococcus aureus; virulence factor; -hemolysin;

机译：抗毒力;水合morin;金黄色葡萄球菌;毒力因子;-溶血素;

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专利

1. Morin hydrate attenuates Staphylococcus aureus virulence by inhibiting the self-assembly of alpha-hemolysin [J] . Wang J., Zhou X., Liu S., Journal of applied microbiology . 2015,第3期

机译：桑色素水合物通过抑制α-溶血素的自组装而减弱金黄色葡萄球菌的毒力
2. Uncariitannin, a polyphenolic polymer from Uncaria gambier, attenuates Staphylococcus aureus virulence through an MgrA-mediated regulation of alpha-hemolysin [J] . Zhang Hong, Jiang Jia-Ming, Han Li, Pharmacological research: The official journal of The Italian Pharmacological Society . 2019,第期

机译：undariitannin，一种来自婴儿冈比特的多酚聚合物，通过MGRA介导的α-溶血素调节衰减金黄色葡萄球菌毒力
3. Chalcone Attenuates Staphylococcus aureus Virulence by Targeting Sortase A and Alpha-Hemolysin [J] . Bing Zhang, Zihao Teng, Xianhe Li, Frontiers in Microbiology . 2017,第1期

机译：查尔酮通过靶向分选酶A和α-溶血素来减轻金黄色葡萄球菌的毒性
4. An Auto-Assembling Staphylococcus aureus Alpha-Hemolysin as a Vaccine Mimicking Natural Immune Response Against the Toxin [C] . Vincenzo Nardi-Dei, Luigi Fiaschi, Benedetta Di Palo, PEGS . 2014

机译：一种自动组装的金黄色葡萄球菌α-溶血素作为模仿毒素的自然免疫应答的疫苗
5. Methicillin-Resistant Staphylococcus aureus: Molecular Epidemiology, Virulence in Disease, and Antibiotic Modulation of Virulence [D] . Yamaki, Jason. 2013

机译：耐甲氧西林金黄色葡萄球菌：分子流行病学，疾病中的毒力和毒力的抗生素调节
6. Chalcone Attenuates Staphylococcus aureus Virulence by Targeting Sortase A and Alpha-Hemolysin [O] . Bing Zhang, Zihao Teng, Xianhe Li, -1

机译：查尔酮通过靶向分选酶A和α-溶血素来减轻金黄色葡萄球菌的毒性。
7. Morin hydrate attenuates Staphylococcus aureus virulence by inhibiting the self-assembly of α-hemolysin [O] . J. Wang, X. Zhou, S. Liu, 2015

机译：Morin水合物通过抑制α-溶血素的自组装来衰减金黄色葡萄球菌毒力

Morin hydrate attenuates Staphylococcus aureus virulence by inhibiting the self-assembly of alpha-hemolysin

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