A novel approach for the detection of early gastric cancer: Fluorescence spectroscopy of gastric juice

摘要

Objective: This study aimed to investigate the efficacy of fluorescence spectroscopy of gastric juice for early gastric cancer (EGC) screening. Methods: Gastric juice was collected from 101 participants who underwent endoscopy in the Outpatient Endoscopy Center of Peking University Third Hospital. The participants were divided into three groups: the normal mucosa or chronic non-atrophic gastritis (NM-CNAG) group (n=35), advanced gastric cancer (AGC) group (n=33) and EGC group (n=33). Fluorescence spectroscopic analysis was performed in all the gastric juice samples and the maximum fluorescence intensity of the first peak (P1FI) was measured. Results: The mean fluorescence intensity of P1FI of gastric juice in AGC (92.1±10.7) and EGC (90.8±12.0) groups was significantly higher than that in the NM-CNAG group (55.7±7.5) (AGCvsNM-CNAG, P=0.006 and EGCvsNM-CNAG, P=0.015, respectively). The areas under the receiver operating characteristic curves for the detection of AGC and EGC were 0.681 (95% confidence interval [CI] 0.553-0.810, P=0.010) and 0.655 (95% CI 0.522-0.787, P=0.028). With the P1FI of ≥47.7, the sensitivity, specificity and accuracy for detecting EGC were 69.7%, 57.1% and 63.2%, respectively. Conclusions: The enhancement of P1FI of gastric juice occurs at the early stage of gastric cancer. Fluorescence spectroscopy of gastric juice may be used as a novel screening tool for the early detection of gastric cancer.