An Improvement of Oxidative Stress in Diabetic Rats by Ubiquinone-10 and Ubiquinol-10 and Bioavailability after Short- and Long-Term Coenzyme Q10 Supplementation

摘要

This study explored effects of ubiquinol-10 and ubiquinone-10, two different forms of coenzyme Q10, in diabetic rats. Oxidative stress is characterized by the depletion of antioxidant defenses and overproduction of free radicals that might contributeto, and even accelerate, the development of diabetes mellitus (DM) complications. Coenzyme Qio was administered orally to diabetic rats and oxidative stress markers were then assessed. Bioavailability in normal rats was additionally assessed in various tissues and subcellular fractions after short-term and long-term coenzyme Qio supplementation. Elevated nonfasting blood glucose and blood pressure in diabetic rats were decreased by ubiquinone-10. Both ubiquinol-10 and ubiquinone-10 ameliorated oxidativestress, based on assays for reactive oxygen metabolites and malondi-aldehyde. Coenzyme Qio levels increased with both treatments and liver nicotinamide adenine dinucleotide phosphate (NADPH) coenzyme 0 reductase with ubiquinone-10. Ubiquinol-10 was better absorbed in the liver and pancreas than ubiquinone-10, though both were similarly effective. In bioavailability study, a longer period of coenzyme Qio supplementation did not lead to its accumulation in tissues or organelles. Both forms of coenzyme Qio reduced oxidative stress in diabetic rats. Long-term supplementation of coenzyme Qio appeared to be safe.