trans-Dichloro(η~2-ethylene) (N-3-pyridinylmethanesulfonamide)platinum(II). Crystal structure, spectroscopic, and thermoanalytical characterization, and cytotoxicity assays

摘要

The organometallic complex, trans-[PtCl_2(η~2-C_2H_4)(PMSA)] (1), where PMSA = N-3-pyridi-nylmethanesulfonamide, has been synthesized and characterized by elemental analysis, molar electric conductivity, IR, electronic, and NMR (~1H, ~(13)C, and ~(195)Pt) spectroscopy, and thermal analysis. X-ray crystallography revealed that in 1 [monoclinic, P2_1C, a = 5.1260(1), b= 19.1600(4), c=12.7990(3)A, β = 97.242(2)°, Z = 4] Pt(II) shows planar coordination geometry with PMSA coordinated via the pyridine. The ethylene is virtually perpendicular to the PtCl_2N plane with the pyridine ring twisted relative to this plane by 47°. In in vitro assays, PMSA, K[PtCl_3(η2-C_2H_4)] . H_2O, and 1 do not exhibit appreciable cytotoxic activity against human K562 and HepG2 tumor cell lines.