Synthesis and application of mononuclear platinum (II) compounds as cytotoxic agents mimetics to cis - Platinum

摘要

The present invention patent has the objective of a composition based on the synergetic effect of the organic compounds L1: 1 - {2 - (2 - (4-hydroxybenzyl piridilmetil) amino) - 3 - (1-naphthyloxy) - 2-propanol and L2: 1 - {2 -4-hydroxybenzyl (2 - piridilmetil) amino) - 3 - (2 - naftiloxi) - 2-propanol and salt of platinum K2 [PtCl4], for the subsequent production of cytotoxic agents similar to the drug cis platinum.Related to the area of medicinal inorganic chemistry. The present invention patent is applied to the pharmaceutical industry.Based on the results of the test cell viability (MTT)It is concluded that platinum compounds presented in this invention patent with high cytotoxic activity against all strains studied.Which is dependent on the structure of the organic binder.The compounds investigated were more cytotoxic to cancer cells than in normal human cells (PBMC), presenting selectivity similar to that of cisplatin.The results of labeling with annexin V and PI.Evaluation of cell cycle (sub G1) and measures the potential of mitochondrial membrane show that the type of death induced by complex 2 is necrosis and by complex 1 is apoptosis.With involvement of the mitochondria, indicating that the complex of platinum 1 is more promising in the development of new anticancer drugs.