Synthesis, Characterization and Cytotoxicity of Ammine/Methylamine Platinum(Ⅱ) Complexes with Carboxylates

摘要

Seven novel platinum（Ⅱ） complexes [Pt（Ⅱ）（NH3）（CH3NH2）X2]（Ⅰ—Ⅶ）（X: CH3COO -, CH2ClCOO-, CHCl 2COO -, C 6H 5—COO -, p-CH 3O—C 6H 4—COO -, p-NH 2—C 6H 4—COO -, p-NO 2—C 6H 4—COO -） were prepared and characterized by means of elemental analysis, molar conductivity, thermal analysis, IR, UV, and 1H NMR spectrometries. The cytotoxicity against HCT-8, BGC-823, MCF-7, EJ, and HL-60 cell lines increases in the following sequence: cisplatin>Ⅳ>Ⅴ>Ⅵ>Ⅶ>Ⅰ>Ⅱ>Ⅲ. Moreover, the complexes（ Ⅰ—Ⅶ） display substantially greater activities against EJ and HL-60 cell lines than those against the cell lines from other carcinomas. They can induce a concentration-dependent accumulation of HL-60 cells in the G 2/M phase of the cell cycle as cisplatin. There is no significant correlation between total DNA platination levels and cytotoxicity of the complexes.