Association of genetic variations in X-Ray repair cross-complementing group 1 and tourette syndrome

摘要

Background: X-ray repair cross-complementing group 1 (XRCC1) plays a central role in mammalian DNA repair process. The polymorphism rs25487 (Arg>Gln at codon 399) of this gene is common in Han Chinese population. Objectives: The objective of this study was to analyze the association between this functional SNP of XRCC1 and Tourette syndrome (TS) in Han Taiwan Chinese population. Methods: Genotyping was performed by using PCR-RFLP method on 73 TS patients and 158 normal controls. Results: Our data indicated that genotype frequency of A/G polymorphism at codon 399 of the patients differed from the controls (P = 0.026, OR: 2.22, 95% CI: 1.22-4.03). The allele frequency analysis also showed significant differences with higher A allele frequency in patients (P = 0.015, OR: 1.70, 95% CI: 1.11-2.62). Conclusion: Our study indicates that the functional SNP at codon 399 of XRCC1 is associated with TS development.