Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma

Curry William T. Jr.; Gorrepati Ramana; Piesche Matthias; Sasada Tetsuro; Agarwalla Pankaj; Jones Pamela S.; Gerstner Elizabeth R.; Golby Alexandra J.; Batchelor Tracy T.; Wen Patrick Y.; Mihm Martin C.; Dranoff Glenn

首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma

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Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma

机译：放射自体肿瘤细胞与放射GM-K562细胞混合接种疫苗可刺激复发性恶性神经胶质瘤患者的抗肿瘤免疫力和T淋巴细胞活化

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Purpose: Recurrent malignant glioma carries a dismal prognosis, and novel therapies are needed. We examined the feasibility and safety of vaccination with irradiated autologous glioma cells mixed with irradiated GM-K562 cells in patients undergoing craniotomy for recurrent malignant glioma.

机译：目的：复发性恶性神经胶质瘤预后不良，需要新的疗法。我们检查了在接受开颅手术治疗复发性恶性神经胶质瘤的患者中，用放射自体神经胶质瘤细胞与放射GM-K562细胞混合接种疫苗的可行性和安全性。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2016年第12期|共12页
作者
Curry William T. Jr.; Gorrepati Ramana; Piesche Matthias; Sasada Tetsuro; Agarwalla Pankaj; Jones Pamela S.; Gerstner Elizabeth R.; Golby Alexandra J.; Batchelor Tracy T.; Wen Patrick Y.; Mihm Martin C.; Dranoff Glenn;
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正文语种 eng
中图分类肿瘤学;
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1. Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma [J] . Curry William T. Jr., Gorrepati Ramana, Piesche Matthias, Clinical cancer research: an official journal of the American Association for Cancer Research . 2016,第12期

机译：放射自体肿瘤细胞与放射GM-K562细胞混合接种疫苗可刺激复发性恶性神经胶质瘤患者的抗肿瘤免疫力和T淋巴细胞活化
2. Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma. [J] . Soiffer R, Hodi FS, Haluska F, Journal of Clinical Oncology . 2003,第17期

机译：通过腺病毒介导的基因转移对经过工程处理以分泌粒细胞巨噬细胞集落刺激因子的辐射自体黑素瘤细胞进行疫苗接种，可提高转移性黑素瘤患者的抗肿瘤免疫力。
3. Malignant Glioma Therapy by Vaccination with Irradiated C6 Cell-Derived Microvesicles Promotes an Antitumoral Immune Response [J] . Benjamín Pineda, Francisco Javier Sánchez García, Nora Karen Olascoaga, Molecular therapy: the journal of the American Society of Gene Therapy . 2019,第9期

机译：用辐照的C6细胞衍生的微泡疫苗接种恶性胶质瘤治疗促进了抗肿瘤免疫应答
4. Increasing the efficacy of antitumor glioma vaccines by photodynamic therapy and local injection of allogeneic glioma cells [C] . Catherine E. Christie, Qian Peng, Steen J. Madsen, Clinical and translational neurohotonics; neural imaging and sensing; and optogenetics and optical manipulation . 2016

机译：通过光动力疗法和局部注射同种异体神经胶质瘤细胞提高抗肿瘤神经胶质瘤疫苗的功效
5. Endogenous antitumor immunity elicited by adoptively transferred lymphocytes through CCL5 and CD40L signaling, and dendritic cell depletion. [D] . Nesbeth, Yolanda C. 2010

机译：过继转移的淋巴细胞通过CCL5和CD40L信号传导以及树突状细胞耗竭引发内源性抗肿瘤免疫力。
6. Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Anti-tumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma [O] . William T. Curry Jr, Ramana Gorrepati, Matthias Piesche, -1

机译：放射自体肿瘤细胞与放射GM-K562细胞混合接种疫苗可刺激复发性恶性神经胶质瘤患者的抗肿瘤免疫力和T淋巴细胞活化
7. Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma [O] . William T. Curry, Ramana Gorrepati, Matthias Piesche, 2016

机译：用辐照的GM-K562细胞混合的辐照自体肿瘤细胞疫苗接种刺激反复性恶性胶质瘤患者的抗肿瘤免疫和T淋巴细胞活化
8. Autologous Rosette-Forming T Cells Regulate Responses of T Cells: Phenotypic and Functional Analysis of Suppressor Cells Generated from Autologous Rosette-Forming T Cells after Autologous Mixed Lymphocyte Reactions [R] . Kumagai, S., Scher, I., Green, I. 1980

机译：自体玫瑰花结形成T细胞调节T细胞的反应：自体混合淋巴细胞反应后由自体玫瑰花结形成T细胞产生的抑制细胞的表型和功能分析

Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma

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