ASYMMETRIC SYNTHESIS OF NAPROXEN BY A NEW HETEROGENEOUS CATALYST

摘要

A new heterogeneous, asymmetric catalyst is described. The catalyst is a modified version of the supported aqueous-phase catalyst reported previously (Wan and Davis, J. Catal. 148, 1 (1994)); ethylene glycol is used in place of water as the hydrophilic phase. Both the enantioselectivity and the activity of this new heterogeneous catalyst are comparable to the homogeneous analogue in neat methanol (or ethylene glycol); e.e.'s are 95.7% vs 96.1% and t.o.f.'s are 40.7 hr(-1) vs 131.0 hr(-1), respectively. Recycling of the catalyst is possible without leaching of ruthenium at a detection limit of 32 ppb. (C) 1995 Academic Press, Inc. [References: 9]