One-pot synthesis of trans-4-alkylthio- and 4-arylthio-cinnamic acidsfrom trans-4-chlorosulfonylcinnamic acid in an aqueous medium

摘要

A one-pot syntheses of trans-4-alkylthio- and 4-arylthio-cinnamic acids were achieved in high yields by reductionof trans-4-chlorosulfonylcinnamic acid with stannous chloride dihydrate followed by alkylation and arylation of theresulting trans-4-thiocinnamic acid with various kinds of alkyl and activated aryl halides in an aqueous medium.