A facile one-pot synthesis and heterocyclisation of (R)-2-amino-3-((aroylcarbamothioyl)thio)propanoic acids

摘要

A series of (R)-2-amino-3-((aroylcarbamothioyl)thio)propanoic acid derivatives have been synthesised by a one-pot， three- component reaction of L-cysteine with ammonium thiocyanate in the presence of various acid chlorides under solvent-free conditions in excellent yields. These compounds were converted to (R)-2-thioxothiazolidine-4-carboxylic acid in water under reflux conditions.