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METHOD FOR SYNTHESIZING L-(-)-2-AMINO-3-(3,4- DIHYDROXYPHENYL)PROPANOIC ACID, PRODUCT THEREBY, AND USE OF SAID PRODUCT IN SAID SYNTHESIS
METHOD FOR SYNTHESIZING L-(-)-2-AMINO-3-(3,4- DIHYDROXYPHENYL)PROPANOIC ACID, PRODUCT THEREBY, AND USE OF SAID PRODUCT IN SAID SYNTHESIS
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机译:合成L-(-)-2-氨基-3-(3,4-二羟基苯酚)丙酸的方法,产物及其在合成中的用途
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摘要
New process for the synthesis of the levodopa, L-(-)-2-amino-3-(3,4-dihydroxyphenyl)propionic acid, drug used in the treatment of the Parkinson's disease. The process consists in resolving with d-camphorsulfonic acid, or with a salt thereof,the d,l-2-amino-3-(3,4-dimethoxyphenyl)propionitrile, obtained from the 3,4-dimethoxyphenylacetaldehyde, and in the subsequent hydrolysis and methylation, by means of concentrated solutions of haloid acids, of the d-2-amino-3-(3,4-dimethoxyphenyl)propionitrile and of salts thereof.
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