Library Synthesis Using 5,6,7,8-Tetrahydro-1,6-naphthyridines as Scaffolds

Ya Zhou; Aaron B. Beeler; Sanghyun Cho

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Library Synthesis Using 5,6,7,8-Tetrahydro-1,6-naphthyridines as Scaffolds

机译：使用5,6,7,8-四氢-1,6-萘啶作为骨架的文库合成

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The chemistry of 5,6,7,8-tetrahydro-1,6-naphthyridine scaffolds, synthesized by intramolecular cobalt-catalyzed [2 + 2 + 2] cyclizations, has been exploited for library synthesis. Urea, amide, and sulfonamide formations were used in the synthesis of a 101-membered library. Screening of the library for antituberculosis activity revealed three lead compounds.

机译：通过分子内钴催化的[2 + 2 + 2]环化合成的5,6,7,8-四氢-1,6-萘啶骨架的化学性质已用于文库合成。尿素，酰胺和磺酰胺形成物用于合成101元文库。筛选抗结核活性的文库揭示了三种先导化合物。

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《Journal of combinatorial chemistry》 |2008年第4期|共7页
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Ya Zhou; Aaron B. Beeler; Sanghyun Cho;
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正文语种 eng
中图分类化学;
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1. Library Synthesis Using 5,6,7,8-Tetrahydro-1,6-naphthyridines as Scaffolds [J] . Ya Zhou, Aaron B. Beeler, Sanghyun Cho Journal of combinatorial chemistry . 2008,第4期

机译：使用5,6,7,8-四氢-1,6-萘啶作为骨架的文库合成
2. Synthesis of 5-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridines and 5-phenyl-6,7,8,9-tetrahydro-5H-pyrido[3,2-c]azepines as potential D1 receptor ligands [J] . Hussenether T, Troschutz R Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 2004,第6期

机译：5-苯基-5,6,7,8-四氢-1,6-萘啶和5-苯基-6,7,8,9-四氢-5H-吡啶并[3,2-c] a庚烷的合成作为潜在的D1受体配体
3. Bridged 5,6,7,8-Tetrahydro-1,6-naphthyridines, Analogues of Huperzine A: Synthesis, Modelling Studies and Evaluation as Inhibitors of Acetylcholinesterase [J] . Vanlaer S, Voet A, Gielens C, European journal of organic chemistry . 2009,第5期

机译：桥接的5,6,7,8-四氢-1,6-萘啶，石杉碱甲类似物：乙酰胆碱酯酶抑制剂的合成，建模研究和评估
4. Synthesis and properties of ~(13)C-labeled naphthyridine derivative [C] . Shuhei Sakurabayashi, Takeshi Yamada, Gota Kawai 日本化学会春季年会 . 2020

机译：〜（13）C标记萘吡啶衍生物的合成与性质
5. Preparation of 5,6,7,8-tetrahydro-1,6-naphthyridines and other heterocyclic scaffolds and their application in library synthesis. [D] . Zhou, Ya. 2008

机译：5,6,7,8-四氢-1,6-萘啶和其他杂环骨架的制备及其在文库合成中的应用。
6. 1234-Tetrahydro-15-naphthyridines and related heterocyclic scaffolds: Exploration of suitable chemistry for library development [O] . Grace H. C. Woo, Aaron B. Beeler, John K. Snyder -1

机译：1234-四氢-15-萘啶和相关杂环支架：探索适合图书馆开发的化学方法
7. Antivertigo agents. IV. Synthesis and antivertigo activity of 6-(.OMEGA.-(4-aryl-1-piperazinyl)alkyl)-5,6,7,8-tetrahydro-1,6-naphthyridines. [O] . AKIRA SHIOZAWA, YUHICHIRO ICHIKAWA, CHIKARA KOMURO, 1984

机译：防舞剂。 IV。 6 - （4-ω-（4-芳基-1-哌嗪基）烷基）的合成和抗激肽活性。 - （4-芳基-1-哌嗪基）烷基）-5,6,7,8-四氢-1,6-萘啶。
8. Metal Atom Synthesis of Metallaboron Clusters. 8. Synthesis of New Cobalt, Iron, and Nickel Clusters Derived from 2,6-C2B7H11. Structural Characterization of 2-ETA 6-C6(CH3)3H3 Fe-1,6-C2B7H9, 6-ETA 6-C6(CH3)3H3 Fe-9,10-C2B7H11, an [R] . Sneddon, L. G., Briguglio, J. J. 1986

机译：metallaboron团簇的金属原子合成。 8.衍生自2,6-C2B7H11的新的钴，铁和镍簇的合成。 2-ETa 6-C6（CH3）3H3Fe-1,6-C2B7H9,6-ETa6-C6（CH3）3H3Fe-9,10-C2B7H11的结构表征

Library Synthesis Using 5,6,7,8-Tetrahydro-1,6-naphthyridines as Scaffolds

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