DERIVATIVE OF 3-OXADIAZOLYL-5,6,7,8-TETRAHYDRO-1,6-NAPHTIRIDINE AND DERIVATIVE OF 5,6,7,8-TETRAHYDRO-1,6-NAPHTIRIDINE

摘要

FIELD: organic chemistry; medicine. SUBSTANCE: derivatives of 3-oxadiazolyl-5,6,7,8-tetrahydro-1,6-naphtiridine are prepared by intramolecular cyclization of suitable acetylsemicarbazides or 1,2-di(R-carbamoyl)hydrazines, the process takes place in the presence of dehydration agent. Desired 6-benzyl-3-(5-methylthio-1,3,4-oxadiazole-2-yl)-5,6,7,8-tetrahydro-1,6- naphtiridine-2(1H)-on is prepared at 55.5 % yield, its melting point being 215-217 C. EFFECT: improved quality of desired product. 10 cl, 8 tbl