In Situ Generation of Carbon Monoxide from Solid Molybdenum Hexacarbonyl. A Convenient and Fast Route to Palladium-Catalyzed Carbonylation Reactions

摘要

During the past 10 years, the techniques of high-throughput chemistry have evolved in pharmaceutical industry to meet its demand for new substances with beneficial therapeutic profiles. These modern methodologies focus on an automated handling of a large number of samples rather than on advanced experimental techniques for gas handling and distribution. For applications that require heating in conjunction to gaseous reagents, closed reaction vessels make up the only suitable preparative procedure. In addition, no commercial single-mode microwave synthesizers with the possibility of using reactive gases under pressure are available. The development of fast, reliable, and convenient gaseous protocols for chemistry is therefore important for the chemical development of high-throughput chemistry in general and high-speed microwave-mediated chemistry in particular. We herein report on a new protocol utilizing easily handled molybdenum hexacarbonyl as a condensed source of carbon monoxide for performing carbonylation reactions.