Solid-Phase Synthesis of 2-Pyridones, 1,4-Diazepines, and 1,4-Oxazepines from Resin-Bound 3-Amino-2-seleno Ester

摘要

A versatile combinatorial approach was developed for the rapid synthesis of 2-pyridones, 1,4-diazepines, and 1,4-oxazepines libraries. The synthetic strategy includes electrophilic addition, nucleophilic substitution, amine-acid condensation, Dieckmann condensation, lactamization, ester hydrolysis, lactonization, and oxidation—elimination.