A convenient synthesis of CF3-containing alkynyl imines by a copper-free Sonogashira coupling of imidoyl chlorides with terminal alkynes

摘要

A series of N-aryltrifluoroacetimidoyl chlorides and 1-alkynes were converted into a-imino alkynes by a Sonogashira reaction using Pd(PPh3)(4)/DABCO as the catalyst. The reaction proceeded smoothly to give the coupled products in good to excellent yields.