Severe Exacerbation of Psychosis After Sudden Withdrawal of Chlorpromazine in the Treatment of Methamphetamine-Associated Psychosis With Aripiprazole and Chlorpromazine: 2 Case Reports

摘要

Objectives: Methamphetamine is commonly associated with psychosis, which may be due to imbalance in dopamine. Aripiprazole is an antipsychotic drug that shows a partial agonistic activity at D-2 receptors. This may lead in some cases to an exacerbation of psychotic symptoms due to dopamine agonism when there is sudden withdrawal of chlorpromazine.