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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Prostaglandin E2 (PGE2) and risedronate was superior to PGE2 alone in maintaining newly added bone in the cortical bone site after withdrawal in older intact rats.
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Prostaglandin E2 (PGE2) and risedronate was superior to PGE2 alone in maintaining newly added bone in the cortical bone site after withdrawal in older intact rats.

机译:前列腺素E2(PGE2)和利塞膦酸盐优于单独使用PGE2,在老年完整大鼠退出后在皮质骨部位保持新添加的骨。

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The objects of this study were (1) to determine the effects of risedronate (Ris) and prostaglandin E2 (PGE2) alone and in combination, on tibial diaphyses of older intact female rats; and (2) to observe the fate of any extra bone if formed after withdrawal of the treatment. Nine-month-old female Sprague-Dawley rats were treated with 6 mg of PGE2/kg/day, 1 or 5 micrograms of Ris/kg twice a week, or 6 mg of PGE2/kg/day plus 1 or 5 micrograms of Ris/kg twice a week for the first 60 days and followed by vehicle injections for another 60 days. Cross-sections of double fluorescent labeled, undecalcified tibial diaphyses proximal to the tibiofibular junction were processed for histomorphometry. We found that: (1) neither the 1 microgram nor the 5 micrograms of Ris treatment in the 60-day on/60-day off group showed any histomorphometric differences from age-related controls; (2) while the 60 days of PGE2 treatment added extra cortical bone (6%) on the tibial shaft (due to stimulation of periosteal, endocortical, and marrow trabecular bone formation), the new endocortical and most of the new marrow trabecular bone were lost when treatment was withdrawn; however, the new periosteal bone remained; (3) PGE2 with Ris added the same amount of new bone to tibial diaphysis as did PGE2 alone and upon withdrawal, new marrow trabecular bone was lost but new periosteal and endocortical bones were preserved in PGE2 + 1 microgram of Ris on/off group. In contrast, all the new bone was maintained in the PGE2 + 5 micrograms of Ris on/off group; (4) PGE2 + Ris cotreatment failed to block the increase in cortical bone porosity induced by PGE2; and (5) in the PGE2 alone and PGE2 + 1 microgram of Ris on/off groups bone turnover was higher than that in the PGE2 + 5 micrograms of Ris on/off group. These results indicate that on/off treatment with PGE2 and Ris is superior to PGE2 alone in that it forms the same amount of new bone during treatment, but preserves more cortical bone during withdrawal. Depression of bone resorption and turnover were the tissue mechanisms responsible for this protection.
机译:这项研究的目的是(1)确定单独使用或联合使用利塞膦酸盐(Ris)和前列腺素E2(PGE2)对完整无缺的雌性大鼠胫骨干phy的影响; (2)观察在戒断治疗后形成的多余骨头的命运。对9个月大的Sprague-Dawley雌性大鼠进行每周两次两次的6 mg PGE2 / kg /天,1或5毫克Ris / kg或6 mg PGE2 / kg /天,1或5毫克Ris的治疗/ kg,前60天每周两次,然后再注射60天。胫骨腓骨交界处的双荧光标记未脱钙胫骨干骨的横截面进行组织形态测定。我们发现:(1)60天开/ 60天休组的1毫克或5毫克Ris治疗均未显示与年龄相关对照组的任何组织形态学差异; (2)60天的PGE2治疗在胫骨干上增加了额外的皮质骨(6%)(由于刺激了骨膜,皮质内层和骨髓小梁的形成),新的皮质内层和大多数新的骨髓小梁是撤回治疗后迷路;然而,新的骨膜仍保留着。 (3)带有Ris的PGE2向胫骨干physi端添加了与单独的PGE2相同数量的新骨,停药后丢失了新的骨髓小梁骨,但在PGE2 + 1微克Ris开/关组中保留了新的骨膜和皮质骨。相反,所有新骨头都保留在PGE2 + 5微克Ris开/关组中; (4)PGE2 + Ris联合治疗不能阻止PGE2引起的皮质骨孔隙增加; (5)在单独的PGE2和PGE2 + 1微克Ris开/关组中,骨转换高于在PGE2 + 5毫克Ris开/关组中。这些结果表明,用PGE2和Ris进行开/关治疗优于单独使用PGE2,因为在治疗过程中它形成相同数量的新骨,但在停药期间保留了更多的皮质骨。抑制骨吸收和周转是造成这种保护的组织机制。

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