...
首页> 外文期刊>Journal of biomedicine & biotechnology >The Combined Effect of Electrical Stimulation and High-Load Isometric Contraction on Protein Degradation Pathways in Muscle Atrophy Induced by Hindlimb Unloading
【24h】

The Combined Effect of Electrical Stimulation and High-Load Isometric Contraction on Protein Degradation Pathways in Muscle Atrophy Induced by Hindlimb Unloading

机译:电刺激和高负荷等距收缩对后肢卸载引起的肌肉萎缩蛋白降解途径的联合作用

获取原文
获取原文并翻译 | 示例

摘要

High-load isometric exercise is considered an effective countermeasure against muscle atrophy, but therapeutic electrical stimulation for muscle atrophy is often performed without loading. In the present study, we investigated the combined effectiveness of electrical stimulation and high-load isometric contraction in preventing muscle atrophy induced by hindlimb unloading. Electrical stimulation without loading resulted in slight attenuation of muscle atrophy. Moreover, combining electrical stimulation with high-load isometric contraction enhanced this effect. In electrical stimulation without loading, inhibition of the overexpression of calpain 1, calpain 2, and MuRF-1 mRNA was confirmed. On the other hand, in electrical stimulation with high-load isometric contraction, inhibition of the overexpression of cathepsin L and atrogin-1 mRNA in addition to calpain 1, calpain 2, and MuRF-1 mRNA was confirmed. These findings suggest that the combination of electrical stimulation and high-load isometric contraction is effective as a countermeasure against muscle atrophy.
机译:高负荷的等距运动被认为是对抗肌肉萎缩的有效对策,但是肌肉萎缩的治疗性电刺激通常是在没有负荷的情况下进行的。在本研究中,我们调查了电刺激和高负荷等距收缩在预防后肢卸载引起的肌肉萎缩方面的综合效果。没有负荷的电刺激导致肌肉萎缩略有减弱。此外,将电刺激与高负荷等距收缩相结合可增强此效果。在无负荷的电刺激中,证实抑制了钙蛋白酶1,钙蛋白酶2和MuRF-1 mRNA的过度表达。另一方面,在高负荷等距收缩的电刺激中,除了钙蛋白酶1,钙蛋白酶2和MuRF-1 mRNA以外,还证实了组织蛋白酶L和atrogin-1 mRNA的过表达被抑制。这些发现表明,电刺激和高负荷等距收缩相结合可以有效地对抗肌肉萎缩。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号