首页> 外文期刊>Biochimica et Biophysica Acta. Molecular and cell biology of Lipids >The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane trafficking
【24h】

The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane trafficking

机译:Sec14超家族和磷脂代谢与膜运输之间的调节接口。

获取原文
获取原文并翻译 | 示例
           

摘要

A central principle of signal transduction is the appropriate control of the process so that relevant signals can be detected with fine spatial and temporal resolution. In the case of lipid-mediated signaling, organization and metabolism of specific lipid mediators is an important aspect of such control. Herein, we review the emerging evidence regarding the roles of Sec14-like phosphatidylinositol transfer proteins (PITPs) in the action of intracellular signaling networks; particularly as these relate to membrane trafficking. Finally, we explore developing ideas regarding how Sec14-like PITPs execute biological function. As See 14-like proteins define a protein superfamily with diverse lipid (or lipophile) binding capabilities, it is likely these under-investigated proteins will be ultimately demonstrated as a ubiquitously important set of biological regulators whose functions influence a large territory in the signaling landscape of eukaryotic cells. (c) 2007 Elsevier B.V. All rights reserved.
机译:信号转导的中心原理是对过程的适当控制,以便可以以良好的空间和时间分辨率检测相关信号。就脂质介导的信号传导而言,特定脂质介体的组织和代谢是此类控制的重要方面。本文中,我们综述了有关Sec14样磷脂酰肌醇转移蛋白(PITPs)在细胞内信号传导网络中的作用的新兴证据;特别是因为这些与膜运输有关。最后,我们探索有关Sec14样PITP如何执行生物学功能的发展思路。正如See 14样蛋白定义具有不同脂质(或亲脂性)结合能力的蛋白超家族一样,这些未充分研究的蛋白可能最终将被证明是普遍存在的重要生物调节剂,其功能影响信号传导领域的广阔领域。真核细胞。 (c)2007 Elsevier B.V.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号