In vitro assessments of CYP and UGT induction, UGT inhibition, transporter interactions, plasma protein binding, and blood-to-plasma partitioning for defibrotide

Luo Gang; Eller Mark; Jung Bonnie; Keehn Ryan; Leitz Sara; Acheson Matthew; Gast Manuela; Bennett Victoria; Albaugh Daniel; Voorman Richard; Zomorodi Katie

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In vitro assessments of CYP and UGT induction, UGT inhibition, transporter interactions, plasma protein binding, and blood-to-plasma partitioning for defibrotide

机译：体外评估CYP和UGT的诱导，UGT抑制，转运蛋白相互作用，血浆蛋白结合以及血纤溶酶

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来源
《Drug Metabolism Reviews》 |2016年第4期|共1页
作者
Luo Gang; Eller Mark; Jung Bonnie; Keehn Ryan; Leitz Sara; Acheson Matthew; Gast Manuela; Bennett Victoria; Albaugh Daniel; Voorman Richard; Zomorodi Katie;
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正文语种 eng
中图分类药理学;
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1. In vitro assessments of CYP and UGT induction, UGT inhibition, transporter interactions, plasma protein binding, and blood-to-plasma partitioning for defibrotide [J] . Luo Gang, Eller Mark, Jung Bonnie, Drug Metabolism Reviews . 2016,第1a4期

机译：体外评估CYP和UGT的诱导，UGT抑制，转运蛋白相互作用，血浆蛋白结合以及血纤溶酶
2. Evaluations of In Vitro Metabolism, Drug-Drug Interactions Mediated by Reversible and Time-Dependent Inhibition of CYPs, and Plasma Protein Binding of MMB4 DMS [J] . S. Peter Hong, Bozena D. Lusiak, Brian L. Burback, International journal of toxicology . 2013,第Suppla2期

机译：体外代谢，CYPs的可逆和时间依赖性抑制介导的药物相互作用和MMB4 DMS血浆蛋白结合的评估
3. Pharmacokinetic, metabolic stability, plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide as potential type 5 phosphodiesterase inhibitors [J] . Haijun Qu, Xiaoxiao Hu, Xiaoli Shi, Animal Cells and Systems . 2019,第3期

机译：N-（2-吡啶基甲基）-2-氢氧甲基-1-吡咯烷基-4-（3-氯-4-甲氧基-苄氨基）-5-嘧啶-的药代动力学，代谢稳定性，血浆蛋白结合和CYP450s抑制/诱导评估研究羧酰胺作为潜在的5型磷酸二酯酶抑制剂
4. Novel approach for pharmacokinetics and plasma protein binding study of teneligliptin using High Resolution Accurate Mass Spectrometer and Ultrafiltration: in-vitro and in-vivo estimation [C] . S. Shanti kumar, B. Prasanth, Ch. Veerabhadra Swamy, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：使用高分辨率精确质谱仪和超滤的Teneligliptin的药代动力学和血浆蛋白结合研究的新方法：体外和体内估计
5. The Intricacies of UGT Regulation: Protein-Protein Interactions and Environmental Arsenic Exposure. [D] . Konopnicki, Camille Maria. 2012

机译：UGT调节的复杂性：蛋白质-蛋白质相互作用和环境砷暴露。
6. Pharmacokinetic metabolic stability plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide as potential type 5 phosphodiesterase inhibitors [O] . Haijun Qu, Xiaoxiao Hu, Xiaoli Shi, 2019

机译：N-（2-吡啶基甲基）-2-羟甲基-1-吡咯烷基-4-（3-氯-4-甲氧基-苄基氨基）-5-嘧啶-的药代动力学代谢稳定性血浆蛋白结合和CYP450s抑制/诱导评估研究羧酰胺作为潜在的5型磷酸二酯酶抑制剂
7. Pharmacokinetic, metabolic stability, plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide as potential type 5 phosphodiesterase inhibitors [O] . Haijun Qu, Xiaoxiao Hu, Xiaoli Shi, 2019

机译：药代动力学，代谢稳定性，血浆蛋白结合和CYP450S抑制/诱导评估N-（2-吡啶甲基）-2-羟基甲基-1-吡咯烷基-4-（3-氯-4-甲氧基 - 苄基氨基）-5-嘧啶 - 羧酰胺作为潜在的5型磷酸二酯酶抑制剂

In vitro assessments of CYP and UGT induction, UGT inhibition, transporter interactions, plasma protein binding, and blood-to-plasma partitioning for defibrotide

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