2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands.

Haubmann C; Hubner H; Gmeiner P

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands.

【24h】

2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands.

机译：2,2-二氰基ovyl作为非芳族芳基生物甾体：高选择性多巴胺D4受体配体的合成，结合实验和SAR研究。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The phenylpiperazinylmethyl substituted pyrrolylmethylenemalononitriles of type 3 and 4 were synthesized and evaluated as strong and selective dopamine D4 receptor ligands.

机译：合成了类型3和4的苯基哌嗪基甲基取代的吡咯基亚甲基丙二腈，并将其评估为强的和选择性的多巴胺D4受体配体。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |1999年第14期|共4页
作者
Haubmann C; Hubner H; Gmeiner P;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
Antipsychotic Agents; Nitriles; Piperazines; Receptors; Dopamine D2; Ligands; 抗精神病剂; 腈类; 哌嗪类; 受体; 多巴胺D2;

机译：Antipsychotic Agents;Nitriles;Piperazines;Receptors;Dopamine D2;Ligands;抗精神病剂;腈类;哌嗪类;受体;多巴胺D2;

相似文献

外文文献
中文文献
专利

1. 2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands. [J] . Haubmann C, Hubner H, Gmeiner P Bioorganic and Medicinal Chemistry Letters . 1999,第14期

机译：2,2-二氰基ovyl作为非芳族芳基生物甾体：高选择性多巴胺D4受体配体的合成，结合实验和SAR研究。
2. Cyclic Amidines as Benzamide Bioisosteres: EPC Synthesis and SAR Studies Leading to the Selective Dopamine D4 Receptor Agonist FAUC 312. [J] . Einsiedel J, Hubner H, Gmeiner P Bioorganic and Medicinal Chemistry Letters . 2003,第5期

机译：环Am作为苯甲酰胺生物等排体：EPC合成和SAR研究导致选择性多巴胺D4受体激动剂FAUC 312。
3. Cyclic Amidines as Benzamide Bioisosteres: EPC Synthesis and SAR Studies Leading to the Selective Dopamine D4 Receptor Agonist FAUC 312. [J] . Einsiedel J, Hubner H, Gmeiner P Bioorganic and Medicinal Chemistry Letters . 2003,第5期

机译：环Am作为苯甲酰胺生物等排体：EPC合成和SAR研究导致选择性多巴胺D4受体激动剂FAUC 312。
4. Discovery, sequencing and synthesis optimization of a highly selective ligand binding an orphan adrenoreceptor subtype in the green mamba venom [C] . Loic Quinton, Celine Rouget, Gilles Mourier, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：高精度配体的发现，测序和合成优化在绿色曼巴纳毒液中结合孤儿肾上腺素亚型的高度选择性配体结合
5. Part One. Synthesis of optically active tryptophan derivatives with potential activity as indoleamine 2,3-dioxygenase inhibitors: An approach via asymmetric catalytic hydrogenation. Part Two. Design, synthesis and pharmacology of selective ligands for alpha1-containing GABA(A)/benzodiazepine receptor subtypes: SAR studies of beta-carbolines at positions -3 and -6 and their corresponding bivalent ligands. Part Three. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. [D] . Yin, Wenyuan. 2007

机译：第一部分。具有吲哚胺2,3-二加氧酶抑制剂潜在活性的旋光色氨酸衍生物的合成：一种通过不对称催化氢化的方法。第二部分。含α1的GABA（A）/苯并二氮杂receptor受体亚型的选择性配体的设计，合成和药理作用：位于-3和-6位的β-咔啉及其相应的二价配体的SAR研究。第三部分。重要生物遗传中间体，（+）-聚神经氨酸和（+）-聚神经氨酸醛，以及16-表-维西辛和Macusine A的首次对映体全合成。
6. Modification of agonist binding moiety in hybrid derivative 5/7-{2-(4-aryl-piperazin-1-yl)-ethyl-propyl-amino}-5678-tetrahydro-naphthalen-1-ol/-2-amino versions: Impact on functional activity and selectivity for dopamine D2/D3 receptors [O] . Bhaskar Gopishetty, Suhong Zhang, Prashant S. Kharkar, -1

机译：杂化衍生物5/7-{2-（4-芳基-哌嗪-1-基）-乙基-丙基-氨基} -5678-四氢萘-1-中激动剂结合部分的修饰ol / -2-氨基形式：对多巴胺D2 / D3受体的功能活性和选择性的影响
7. Dopamine/Serotonin Receptor Ligands. 10:1 SAR Studies on Azecine-type Dopamine Receptor Ligands by Functional Screening at Human Cloned D1, D2L, and D5 Receptors with a Microplate Reader Based Calcium Assay Lead to a Novel Potent D1/D5 Selective Antagonist [O] . -1

机译：多巴胺/血清素受体配体。 10：1通过用克隆D1，D2L和D5受体在人克隆的D1，D2L和D5受体中的功能筛选研究氮杂胺型多巴胺受体配体的SAR研究，该钙测定的微孔板读取器钙测定导致了一种新型效率D1 / D5选择性拮抗剂

2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands.

摘要

著录项

相似文献

相关主题

期刊订阅