New triterpenes from Salacia hainanensis Chun et How with alpha-glucosidase inhibitory activity.

摘要

Fractionation of the methanol extract from the roots of Salacia hainanensis Chun et How showing the potent inhibitory activity on alpha-glucosidase afforded two new lupane derivatives, 3alpha,28-dihydroxy-lup-20(29)-en-2-one (1) and 3alpha-hydroxy-lup-20(29)-en-2-one (2), a new friedelane derivative, D:A-friedo-oleanane-7alpha,30-dihydroxy-3-one (3), and a novel natural product, 2,3-seco-lup-20(29)-en-2,3-dioic acid (4), along with four known compounds (5-8). Their structures were established on the basis of spectral analysis, especially on the data afforded by 2D NMR and high-resolution mass spectra experiments. All of them showed a much stronger inhibiting activity on alpha-glucosidase than the positive control (acarbose, IC = 5.83 muM). Constituents with alpha-glucosidase inhibitory activity from this plant are reported for the first time.